Studies on Human Thyroxine - Binding Globulin
نویسنده
چکیده
to large volumes of serum may be due to adsorption of neuraminidases to the Sepharose either directly from serum or as the result of bacterial contamination. Partial desialylation of TBG in vivo may be an early step in the catabolism of this protein.
منابع مشابه
The effect of plasma on the in vitro uptake or binding by human red cells of radioactive I-131 labeled L-thyroxine and L-triiodothyronine.
Thyroxine is bound to a serum protein which appears in the electrophoretogram just ahead of alpha-2 globulin (1-4). Triiodothyronine also associates with this thyroxine binding globulin (T.B.G.) but can be displaced readily with thyroxine -while triiodothyronine will not readily displace thyroxine. Deiss, Albright, and Larson (5) suggested that the firm binding of thyroxine to T.B.G. might acco...
متن کاملThe Effect of Plasma on the in Vitro Uptake Or
Thyroxine is bound to a serum protein which appears in the electrophoretogram just ahead of alpha-2 globulin (1-4). Triiodothyronine also associates with this thyroxine binding globulin (T.B.G.) but can be displaced readily with thyroxine -while triiodothyronine will not readily displace thyroxine. Deiss, Albright, and Larson (5) suggested that the firm binding of thyroxine to T.B.G. might acco...
متن کاملLack of significant binding of L-triiodothyronine by thyroxine-binding globulin in vivo as demonstrated by acute disappearance of 131-I-labeled triiodothyronine.
Since Gordon and his colleagues' (1) description of the association of thyroxine (T4) with an a-globulin [later termed "thyroxine-binding globulin" (TBG) ] in 1952, thyroid hormone transport has been the subject of intense study. The demonstration of "thyroxine-binding prealbumin" (TBPA) by Ingbar (2) in 1958 provided further understanding of the binding of T4 by the plasma proteins. It has als...
متن کاملBinding of Thyroxine by Human Serum Albumin
In previous work from this laboratory (1) studies on equilibrium dialysis were carried out to determine the binding constants for the interaction of human serum albumin with thyroxine and its analogs. The classical technique of equilibrium dialysis as described by Scatchard and others (2-6) was employed. At present it seems clear that thyroxine in human serum migrates to at least three differen...
متن کاملRapid determination of thyroxine binding proteins of human serum.
A simple method is described for determing thyroxine binding proteins in human serum by electrophoresis at pH 8.6, using cellulose acetate membrane as the supporting medium. The procedure had high reliability in sera of normal subjects, pregnant women and patients with decreased thyroxine binding capacity of thyroxine binding globulin.
متن کاملRadioelectrophoresis for determination of thyroid hormone binding abnormalities in human serum.
This paper describes a rapid and accurate method for determining binding abilities of thyroid hormones to their corresponding serum proteins: prealbumin, albumin and thyroxine binding globulin. A tube cell agarose gel electrophoresis is used with radioactive labelled triiodothyronine or thyroxine. The distribution curve shows characteristic peaks for prealbumin, albumin and thyroxine binding gl...
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